Personalized radiotherapy: concepts, biomarkers and trial design

摘要: In the past decade, and pointing onwards to immediate future, clinical radiotherapy has undergone considerable developments, essentially including technological advances sculpt radiation delivery, demonstration of benefit adding concomitant cytotoxic agents for a range tumour types and, intriguingly, increasing integration targeted therapeutics biological optimization effects. Recent molecular imaging insights into radiobiology will provide unique opportunity rational patient treatment, enabling parallel design next-generation trials that formally examine therapeutic outcome drugs radiation, together with critically important assessment volume dose-limiting treatment toxicities. considering use systemic presumed radiosensitizing activity, this may also include identification molecular, metabolic markers response tolerability, need particular attention on eligibility. addition providing an overview biomarker studies relevant personalized radiotherapy, communication highlight principles in addressing evaluation combined-modality-targeted radiation. The number translational bridge large-scale omics sciences quality-assured phenomics end points—given imperative development open-source data repositories allow investigators access complex sets—will enable oncology continue position itself highest level evidence within existing practice.