Type 2 diabetic individuals have impaired leg blood flow responses to exercise: role of endothelium-dependent vasodilation.

摘要: OBJECTIVE — Diabetic individuals have impaired endothelium-dependent forearm vasodilatory responses to ischemia, acetylcholine, and other agonists. The functional significance of dilation in diabetic is uncertain but most likely be manifest during leg muscle exercise may relevance peripheral vascular disease which prevalent individuals. current study aimed determine the relationship between blood flow (LBF) vasodilation dynamic large exercise. RESEARCH DESIGN AND METHODS LBF (thermodilution) intrafemoral arterial infusions an (acetylcholine) endothelium-independent (sodium nitroprusside) vasodilator a standardized 25-min cycling bout at 60% V o 2peak were compared nine male type 2 subjects age-, sex-, -, weight-matched control subjects. RESULTS acetylcholine not sodium nitroprusside significantly ( P r = 0.54, 0.02). Furthermore, resting plasma glucose was related response −0.66, 0.003) independently insulin, HbA 1c , lipids, BMI, pressure. CONCLUSIONS increase substantially attenuated with matched Impaired secondary elevated underlie this observation. This mechanism importance determining ischemic threshold disease.