Brief review: cell replacement therapies to treat type 1 diabetes mellitus
作者： Alberto Hayek , Charles C. King
DOI: 10.1186/S40842-016-0023-Y
关键词:
摘要: Human embryonic stem cells (hESCs) and induced pluripotent (iPSCs) have the potential to differentiate into any somatic cell, making them ideal candidates for cell replacement therapies treat a number of human diseases regenerate damaged or non-functional tissues organs. Key promise regenerative medicine is developing standardized protocols that can safely be applied in patients. Progress towards this goal has occurred fields, including type 1 diabetes mellitus (T1D). During past 10 years, significant technological advances hESC/iPSC biochemistry provided roadmap generate sufficient quantities glucose-responsive, insulin-producing capable eliminating rodents. Although many molecular mechanisms underlying genesis these remain elucidated, field cell-based therapeutics T1D advanced point where first Phase I/II trials humans begun. Here, we provide concise review history from islet transplantations xenotranplantation, current work hESC/iPSC. We also highlight latest efforts employ insulin-producing, glucose-responsive β-like derived hESC as therapeutics.
biomedcentral.com
springer.com
core.ac.uk
sci-hub.se 参考文章(59)
Gillian M. Beattie, C. Butler, Alberto Hayek, Morphology and Function of Cultured Human Fetal Pancreatic Cells Transplanted into Athymic Mice: A Longitudinal Study Cell Transplantation. ,vol. 3, pp. 421- 425 ,(1994) , 10.1177/096368979400300509
Chung-Gyu Park, Rita Bottino, Wayne J Hawthorne, None, Current status of islet xenotransplantation International Journal of Surgery. ,vol. 23, pp. 261- 266 ,(2015) , 10.1016/J.IJSU.2015.07.703
Martha Campbell-Thompson, Teresa Rodriguez-Calvo, Manuela Battaglia, Abnormalities of the Exocrine Pancreas in Type 1 Diabetes Current Diabetes Reports. ,vol. 15, pp. 79- 79 ,(2015) , 10.1007/S11892-015-0653-Y
J. S. Shin, J. M. Kim, J. S. Kim, B. H. Min, Y. H. Kim, H. J. Kim, J. Y. Jang, I. H. Yoon, H. J. Kang, J. Kim, E. S. Hwang, D. G. Lim, W. W. Lee, J. Ha, K. C. Jung, S. H. Park, S. J. Kim, C. G. Park, Long-term control of diabetes in immunosuppressed nonhuman primates (NHP) by the transplantation of adult porcine islets. American Journal of Transplantation. ,vol. 15, pp. 2837- 2850 ,(2015) , 10.1111/AJT.13345
Christopher A. Bravery, Do human leukocyte antigen-typed cellular therapeutics based on induced pluripotent stem cells make commercial sense? Stem Cells and Development. ,vol. 24, pp. 1- 10 ,(2015) , 10.1089/SCD.2014.0136
Alice Anna Tomei, Chiara Villa, Camillo Ricordi, None, Development of an encapsulated stem cell-based therapy for diabetes Expert Opinion on Biological Therapy. ,vol. 15, pp. 1321- 1336 ,(2015) , 10.1517/14712598.2015.1055242
Dagmar Klein, Silvia Álvarez-Cubela, Giacomo Lanzoni, Nancy Vargas, Kamalaveni R. Prabakar, Maria Boulina, Camillo Ricordi, Luca Inverardi, Ricardo L. Pastori, Juan Domínguez-Bendala, BMP-7 Induces Adult Human Pancreatic Exocrine-to-Endocrine Conversion Diabetes. ,vol. 64, pp. 4123- 4134 ,(2015) , 10.2337/DB15-0688
Evgenios Neofytou, Connor Galen O’Brien, Larry A. Couture, Joseph C. Wu, Hurdles to clinical translation of human induced pluripotent stem cells Journal of Clinical Investigation. ,vol. 125, pp. 2551- 2557 ,(2015) , 10.1172/JCI80575
Ligia F. Gomes, Sandra Lorente, Karin A. Simon-Giavarotti, Kelsy N. Areco, Clóvis Araújo-Peres, Luis A. Videla, Tri-iodothyronine differentially induces Kupffer cell ED1/ED2 subpopulations Molecular Aspects of Medicine. ,vol. 25, pp. 183- 190 ,(2004) , 10.1016/J.MAM.2004.02.018
Michael German, M Lemper, G Leuckx, Y Heremans, MS German, H Heimberg, L Bouwens, L Baeyens, Reprogramming of human pancreatic exocrine cells to β-like cells. Cell Death & Differentiation. ,vol. 22, pp. 1117- 1130 ,(2015) , 10.1038/CDD.2014.193