The different expression of TRPM7 and MagT1 impacts on the proliferation of colon carcinoma cells sensitive or resistant to doxorubicin.
作者： Alessandra Cazzaniga , Claudia Moscheni , Valentina Trapani , Federica I. Wolf , Giovanna Farruggia
DOI: 10.1038/SREP40538
关键词:
摘要: The processes leading to anticancer drug resistance are not completely unraveled. To get insights into the underlying mechanisms, we compared colon carcinoma cells sensitive doxorubicin with their resistant counterpart. We found that growth retarded, and show staminal ultrastructural features profoundly different from cells. phenotype is accompanied by upregulation of magnesium transporter MagT1 downregulation ion channel kinase TRPM7. demonstrate amounts TRPM7 account for proliferation rate It remains be verified whether they also involved in control other "staminal" traits.
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sci-hub.se 参考文章(32)
Feng-Yen Li, Benjamin Chaigne-Delalande, Chrysi Kanellopoulou, Jeremiah C Davis, Helen F Matthews, Daniel C Douek, Jeffrey I Cohen, Gulbu Uzel, Helen C Su, Michael J Lenardo, None, Second messenger role for Mg2+ revealed by human T-cell immunodeficiency Nature. ,vol. 475, pp. 471- 476 ,(2011) , 10.1038/NATURE10246
Loren W Runnels, Lixia Yue, David E Clapham, None, TRP-PLIK, a Bifunctional Protein with Kinase and Ion Channel Activities Science. ,vol. 291, pp. 1043- 1047 ,(2001) , 10.1126/SCIENCE.1058519
Daan Visser, Jeroen Middelbeek, Frank N. van Leeuwen, Kees Jalink, Function and regulation of the channel-kinase TRPM7 in health and disease European Journal of Cell Biology. ,vol. 93, pp. 455- 465 ,(2014) , 10.1016/J.EJCB.2014.07.001
Kristopher Clark, Jeroen Middelbeek, Edwin Lasonder, Natalya G. Dulyaninova, Nick A. Morrice, Alexey G. Ryazanov, Anne R. Bresnick, Carl G. Figdor, Frank N. van Leeuwen, TRPM7 regulates myosin IIA filament stability and protein localization by heavy chain phosphorylation. Journal of Molecular Biology. ,vol. 378, pp. 790- 803 ,(2008) , 10.1016/J.JMB.2008.02.057
Federica I. Wolf, Valentina Trapani, Magnesium and its transporters in cancer: a novel paradigm in tumour development. Clinical Science. ,vol. 123, pp. 417- 427 ,(2012) , 10.1042/CS20120086
J. Jin, B. N. Desai, B. Navarro, A. Donovan, N. C. Andrews, D. E. Clapham, Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. Science. ,vol. 322, pp. 756- 760 ,(2008) , 10.1126/SCIENCE.1163493
Lillia V. Ryazanova, Lusliany J. Rondon, Susanna Zierler, Zhixian Hu, Joanna Galli, Terry P. Yamaguchi, Andrzej Mazur, Andrea Fleig, Alexey G. Ryazanov, TRPM7 is essential for Mg 2+ homeostasis in mammals Nature Communications. ,vol. 1, pp. 109- 109 ,(2010) , 10.1038/NCOMMS1108
Erika Baldoli, Sara Castiglioni, Jeanette A. M. Maier, Regulation and Function of TRPM7 in Human Endothelial Cells: TRPM7 as a Potential Novel Regulator of Endothelial Function PLoS ONE. ,vol. 8, pp. e59891- ,(2013) , 10.1371/JOURNAL.PONE.0059891
Gabriel Arismendi-Morillo, Electron microscopy morphology of the mitochondrial network in human cancer The International Journal of Biochemistry & Cell Biology. ,vol. 41, pp. 2062- 2068 ,(2009) , 10.1016/J.BIOCEL.2009.02.002
Thomas T. Vellinga, Tijana Borovski, Vincent C.J. de Boer, Szabolcs Fatrai, Susanne van Schelven, Kari Trumpi, Andre Verheem, Nikol Snoeren, Benjamin L. Emmink, Jan Koster, Inne H.M. Borel Rinkes, Onno Kranenburg, SIRT1/PGC1α-Dependent Increase in Oxidative Phosphorylation Supports Chemotherapy Resistance of Colon Cancer Clinical Cancer Research. ,vol. 21, pp. 2870- 2879 ,(2015) , 10.1158/1078-0432.CCR-14-2290