Mechanistic Fluid Transport Model to Estimate Gastrointestinal Fluid Volume and Its Dynamic Change Over Time.
作者： Alex Yu , Trachette Jackson , Yasuhiro Tsume , Mark Koenigsknecht , Jeffrey Wysocki
DOI: 10.1208/S12248-017-0145-X
关键词:
摘要: Gastrointestinal (GI) fluid volume and its dynamic change are integral to study drug disintegration, dissolution, transit, absorption. However, key questions regarding the local absorption, secretion, transit remain unanswered. The compartment absorption (DFCAT) model is proposed estimate in vivo GI transport based on magnetic resonance imaging (MRI) quantified volume. was validated using concentration of phenol red human tract, which directly measured by intubation after oral dosing non-absorbable red. ranged from 0.05 168 μg/mL (stomach), 563 μg/mL (duodenum), 202 μg/mL (proximal jejunum), 478 μg/mL (distal jejunum). DFCAT characterized observed MRI changes 275 46.5 mL stomach (from 0 30 min) with mucus layer 40 mL. volumes 30 small intestine compartments were a max 14.98 mL min 0.26 mL (0–120 min) 5 mL per compartment. Regional over 120 min 5.6 20.38 mL proximal intestine, 36.4 44.08 mL distal 42 64.46 mL total intestine. can be applied predict dissolution tract future improvements.
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Rainer Greger, Uwe Windhorst, Comprehensive Human Physiology : From Cellular Mechanisms to Integration ,(1996)
Horace Willard Davenport, Physiology of the digestive tract : an introductory text Year Book Medical Publishers. ,(1971)
Thaher Pelaseyed, Joakim H. Bergström, Jenny K. Gustafsson, Anna Ermund, George M. H. Birchenough, André Schütte, Sjoerd van der Post, Frida Svensson, Ana M. Rodríguez-Piñeiro, Elisabeth E. L. Nyström, Catharina Wising, Malin E. V. Johansson, Gunnar C. Hansson, The mucus and mucins of the goblet cells and enterocytes provide the first defense line of the gastrointestinal tract and interact with the immune system Immunological Reviews. ,vol. 260, pp. 8- 20 ,(2014) , 10.1111/IMR.12182
Per M. Hellström, Per Grybäck, Hans Jacobsson, The physiology of gastric emptying Best Practice & Research Clinical Anaesthesiology. ,vol. 20, pp. 397- 407 ,(2006) , 10.1016/J.BPA.2006.02.002
Masoud Jamei, David Turner, Jiansong Yang, Sibylle Neuhoff, Sebastian Polak, Amin Rostami-Hodjegan, Geoffrey Tucker, Population-Based Mechanistic Prediction of Oral Drug Absorption Aaps Journal. ,vol. 11, pp. 225- 237 ,(2009) , 10.1208/S12248-009-9099-Y
C L Hoad, L Marciani, S Foley, J J Totman, J Wright, D Bush, E F Cox, E Campbell, R C Spiller, P A Gowland, Non-invasive quantification of small bowel water content by MRI: a validation study. Physics in Medicine and Biology. ,vol. 52, pp. 6909- 6922 ,(2007) , 10.1088/0031-9155/52/23/009
Lawrence X. Yu, John R. Crison, Gordon L. Amidon, Compartmental transit and dispersion model analysis of small intestinal transit flow in humans International Journal of Pharmaceutics. ,vol. 140, pp. 111- 118 ,(1996) , 10.1016/0378-5173(96)04592-9
Muriel Derrien, Mark W.J. van Passel, Jeroen H.B. van de Bovenkamp, Raymond Schipper, Willem de Vos, Jan Dekker, Mucin-bacterial interactions in the human oral cavity and digestive tract Gut microbes. ,vol. 1, pp. 254- 268 ,(2010) , 10.4161/GMIC.1.4.12778
H. Lennernäs, L. Aarons, P. Augustijns, S. Beato, M. Bolger, K. Box, M. Brewster, J. Butler, J. Dressman, R. Holm, K. Julia Frank, R. Kendall, P. Langguth, J. Sydor, A. Lindahl, M. McAllister, U. Muenster, A. Müllertz, K. Ojala, X. Pepin, C. Reppas, A. Rostami-Hodjegan, M. Verwei, W. Weitschies, C. Wilson, C. Karlsson, B. Abrahamsson, Oral biopharmaceutics tools - time for a new initiative - an introduction to the IMI project OrBiTo. European Journal of Pharmaceutical Sciences. ,vol. 57, pp. 292- 299 ,(2014) , 10.1016/J.EJPS.2013.10.012
Lawrence X. Yu, Gordon L. Amidon, A compartmental absorption and transit model for estimating oral drug absorption. International Journal of Pharmaceutics. ,vol. 186, pp. 119- 125 ,(1999) , 10.1016/S0378-5173(99)00147-7