Development of (18)F-labeled radiotracers for neuroreceptor imaging with positron emission tomography.
作者： Peter Brust , Jörg van den Hoff , Jörg Steinbach
DOI: 10.1007/S12264-014-1460-6
关键词:
摘要: Positron emission tomography (PET) is an in vivo molecular imaging tool which widely used nuclear medicine for early diagnosis and treatment follow-up of many brain diseases. PET uses biomolecules as probes are labeled with radionuclides short half-lives, synthesized prior to the studies. These called radiotracers. Fluorine-18 a radionuclide routinely radiolabeling neuroreceptor ligands because its favorable half-life 109.8 min. The delivery such radiotracers into provides images transport, metabolic, neurotransmission processes on level. After introduction principles PET, this review mainly focuses strategy radiotracer development bridging from basic science biomedical application. Successful design described here not only useful human diseases, but also allow studies various small-animal models disease, including genetically-engineered animals. Furthermore, they provide powerful pharmacology during process pre-clinical drug identify new targets, investigate pathophysiology, discover potential candidates, evaluate pharmacokinetics pharmacodynamics drugs vivo.
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