Identification of NEK3 and MOK as novel targets for lithium
作者： Ana Bravo , Héctor Lucio , Pedro A. Sánchez‐Murcia , Antonio Jiménez‐Ruiz , Paula M. Petrone
DOI: 10.1111/CBDD.13487
关键词:
摘要: Lithium ion, commonly used as the carbonate salt in treatment of bipolar disorders, has been identified an inhibitor several kinases, including Glycogen Synthase Kinase-3β, for almost 20 years. However, both exact mechanism enzymatic inhibition and its apparent specificity certain metalloenzymes are still a matter debate. A data-driven hypothesis is presented that accounts profile kinase by lithium terms presence unique protein environment magnesium-binding site. This validated discovery two novel potential targets lithium, namely NEK3 MOK, which related to neuronal function.
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