The development of hypophosphataemic osteomalacia with myopathy in two patients with HIV infection receiving tenofovir therapy.

作者: MJ Parsonage , EGL Wilkins , N Snowden , BG Issa , MW Savage

DOI: 10.1111/J.1468-1293.2005.00318.X

关键词:

摘要: We report two cases in which osteomalacia developed patients on tenofovir-containing highly active antiretroviral therapy (HAART) the context of Fanconi syndrome with hypophosphataemia. Bone pain was presenting feature and myopathy followed one case. Disability reversed withdrawal drug mineral supplementation. The highlight importance considering diagnosis treated tenofovir. A possible association incipient acute renal failure, particularly during nonsteroidal anti-inflammatory (NSAID) use, needs further investigation.

参考文章(28)
Hopkins A, Zylstra S, Hreshchyshyn Mm, Anbar M, Effects of natural menopause, hysterectomy, and oophorectomy on lumbar spine and femoral neck bone densities. Obstetrics & Gynecology. ,vol. 72, pp. 631- 638 ,(1988)
D. P. Kotler, Human immunodeficiency virus-related wasting: malabsorption syndromes. Seminars in Oncology. ,vol. 25, pp. 70- 75 ,(1998)
Stephen R. Bindner, Kristen M. Geiger, The downside of snowboarding. Common injuries in novices and those seeking 'hospital air' Postgraduate Medicine. ,vol. 105, pp. 83- 88 ,(1999) , 10.3810/PGM.1999.01.492
Karen E Earle, Tara Seneviratne, Joseph Shaker, Dolores Shoback, Fanconi's syndrome in HIV+ adults: report of three cases and literature review. Journal of Bone and Mineral Research. ,vol. 19, pp. 714- 721 ,(2004) , 10.1359/JBMR.2004.19.5.714
Martha Q. Lacy, Morie A. Gertz, Acquired Fanconi's syndrome associated with monoclonal gammopathies. Hematology-oncology Clinics of North America. ,vol. 13, pp. 1273- 1280 ,(1999) , 10.1016/S0889-8588(05)70126-X
Garabed Eknoyan, Current status of chronic analgesic and nonsteroidal anti-inflammatory drug nephropathy. Current Opinion in Nephrology and Hypertension. ,vol. 3, pp. 182- 188 ,(1994) , 10.1097/00041552-199403000-00008
Karin Weissenborn, Martin Bokemeyer, Jochen Krause, Jochen Ennen, Björn Ahl, Neurological and neuropsychiatric syndromes associated with liver disease. AIDS. ,vol. 19, ,(2005) , 10.1097/01.AIDS.0000192076.03443.6D
Hassane Izzedine, Vincent Launay-Vacher, Corinne Isnard-Bagnis, Gilbert Deray, Drug-induced Fanconi's syndrome American Journal of Kidney Diseases. ,vol. 41, pp. 292- 309 ,(2003) , 10.1053/AJKD.2003.50037
Pablo Tebas, William G. Powderly, Sherry Claxton, Donna Marin, Woraphot Tantisiriwat, Steven L. Teitelbaum, Kevin E. Yarasheski, Accelerated bone mineral loss in HIV-infected patients receiving potent antiretroviral therapy. AIDS. ,vol. 14, ,(2000) , 10.1097/00002030-200003100-00005
Hernando Knobel, Ana Guelar, Gabriel Vallecillo, Xavier Nogués, Adolfo Díez, Osteopenia in HIV-infected patients: is it the disease or is it the treatment? AIDS. ,vol. 15, pp. 807- 808 ,(2001) , 10.1097/00002030-200104130-00022