Well-characterized sequence features of eukaryote genomes and implications for ab initio gene prediction

摘要: In silico analysis of DNA sequences is an important area computational biology in the post-genomic era. Over past two decades, approaches for ab initio prediction gene structure from genome sequence alone have largely facilitated our understanding on a variety biological questions. Although protein-coding genes has already been well-established, we are also facing challenges to robustly find non-coding RNA genes, such as miRNA and lncRNA. Two main aspects include computed values describing features used algorithm training discriminant function, by which different combinations employed into various bioinformatic tools. Herein, briefly review these well-characterized eukaryote genomes applications prediction. The purpose this article provide overview beginners who aim develop related