Translating the ‘Sugar Code’ into Immune and Vascular Signaling Programs

摘要: The vast range and complexity of glycan structures their dynamic variations in health disease have presented formidable challenges toward understanding the biological significance these molecules. Despite limitations, compelling evidence highlights a major role for galectins, family soluble glycan-binding proteins, as endogenous decoders that translate glycan-containing information into broad spectrum cellular responses by modulating receptor clustering, reorganization, endocytosis, signaling. Here, we underscore pioneer findings recent advances biology galectin–glycan interactions myeloid, lymphoid, endothelial compartments, highlighting important pathways which multivalent complexes control immune vascular programs. Implementation novel glycoanalytical approaches, well use genetically engineered cell organism models, allowed glycans galectins to be explored across processes.