Hypertension and impaired renal function accompany juvenile obesity: the effect of prenatal diet.

摘要: Obesity has been suggested to have a detrimental impact on kidney structure and function, leading focal glomerulosclerosis hypertension. It is also associated with hyperleptinemia elevated renal sympathetic nerve activity. Prenatal undernutrition promotes postnatal obesity, hypertension, an altered function. In this study, we examined the effects of prenatal nutrient restriction juvenile obesity in sheep. We found that led chronic reduced function as assessed by nuclear scintigraphy. Additional factors include glomerulosclerosis, increased apoptosis. undernutrition, synchronous early development, coupled postnatally had no effect systemic pathophysiological sequalae per se. Hypertension, hyperleptinemia, poor were all observed group. All indices pathology such expression proinflammatory cytokines, angiotensin II, glucocorticoid receptors, apoptosis entirely absent obese prenatally undernourished offspring. Our data indicate se leads hypertension structural functional pathology. effectively abolishes any histopathology obesity.