Human papillomaviruses and their role in cervical cancer.
作者： G. Dell , K. Gaston
DOI: 10.1007/PL00000827
关键词:
摘要: Human papillomaviruses (HPVs) have been linked to a variety of human diseases, most notably cancer the cervix, disease responsible for at least 200,000 deaths per year worldwide. Over 100 different types HPV identified and these can be divided into two groups. Low-risk are causative agent benign warts. High-risk associated with cancer. This review focuses on role high-risk in cervical tumorigenesis. Recent work has uncovered new cellular partners many early proteins thrown light pathways processes which viral intervene. At same time, structural biochemical studies revealing molecular details protein function. Several avenues research potential lead approaches treatment prevention
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