Transcortical Cooling Inhibits Hippocampal-kindled Seizures in the Rat

摘要: PURPOSE: When epileptogenic regions encroach on eloquent brain, surgery may incur unacceptable deficits. Reversible cooling control seizures while preserving function. We describe the effects of kindled in awake, freely moving rats. METHODS: rats after placement a bipolar electrode and copper coil dorsal hippocampus. Fully animals (three consecutive grade 5 seizures) were cooled to one two target temperatures (24 degrees or 27 C) for 3 min preceding kindling stimulation 2 minutes after. compared seizure score (0-5) afterdischarge duration (ADD) with without cooling. Target confirmed identical by using needle thermocouple advanced circulating coolant. RESULTS: Circulation 16 C 8 coolant reliably achieved transcortical hippocampal 27.0 +/- 1.2 23.8 2.0 C, respectively, 180 s. Cooling (n = 5) significantly reduced scores from 2.57 1.56, ADD 142 94.5 s 45.7 20.5 0.42, 132.3 29.6 55.5 25.9 In 33.3% all stimulations, 0 resulted; recurred during subsequent stimulations when was withheld. CONCLUSIONS: kindled, tonic-clonic can be suppressed aborted periictal target. Anticonvulsant activity occurred at well above those known result tissue injury inhibition normal neurologic These findings have important implications potential use implantable devices humans refractory epilepsies near cortex dominant formations.