摘要: Trastuzumab is a humanized monoclonal antibody that targets the type 1 tyrosine kinase receptor erb-B2 and has demonstrated survival benefit when used in combination with chemotherapy treatment of metastatic, HER2 overexpressing breast cancer. This chapter reviews history development trastuzumab including biology HER signaling, technical issues “humanization,” diagnostic challenges developing “targeted” therapeutic agents, clinical data led to approval this agent for patients
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