MicroRNA 29b functions in acute myeloid leukemia.
作者： Ramiro Garzon , Catherine E. A. Heaphy , Violaine Havelange , Muller Fabbri , Stefano Volinia
DOI: 10.1182/BLOOD-2009-03-211938
关键词:
摘要: MicroRNAs (miRNAs) are associated with cytogenetics and molecular subtypes of acute myelogeneous leukemia (AML), but their impact on AML pathogenesis is poorly understood. We have previously shown that miR-29b expression deregulated in primary blasts. In this work, we investigated the functional role leukemogenesis. Restoration cell lines samples induces apoptosis dramatically reduces tumorigenicity a xenograft model. Transcriptome analysis after ectopic transfection synthetic into cells indicates target apoptosis, cycle, proliferation pathways. A significant enrichment for genes, including MCL-1, was found among mRNAs inversely correlated 45 samples. Together, data support tumor suppressor miR-29 provide rationale use oligonucleotides as novel strategy to improve treatment response AML.
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