The conducted action potential. Models and comparison to experiments

摘要: Propagation of the action potential is a complex process, and relationships among various factors involved in conduction have not been clear. We use three mathematical models uniform cable to clarify some these relationships. One model newly derived here, two previously by Hunter et al. (1975, Prog. Biophys. Mol. Biol., 30:99–144). These were able simulate individual experimental upstrokes obtained (Walton Fozzard, 1983, J., 44:1–8). The then utilized provide between measures conduction. Among that maximal upstroke velocity (Vmax) directly proportional peak inward ionic current normalized capacitance filled during (I/Cf), was related square root either Vmax or I/Cf. shown be independent predict results, thus providing validated quantitative discernible through data alone. concept safety factor considered parameter proposed may factor.