The rise of a novel classification system for endometrial carcinoma; integration of molecular subclasses

摘要: Endometrial cancer is a clinically heterogeneous disease and it becoming increasingly clear that this heterogeneity may be function of the diversity underlying molecular alterations. Recent large-scale genomic studies have revealed endometrial can divided into at least four distinct subtypes, with well-described aberrations. These subtypes reliably delineated carry significant prognostic as well predictive information; embracing incorporating them clinical practice thus attractive. The road towards integration features current classification systems not without obstacles. Collaborative engaging research teams from across world are working to define pragmatic assays, improve risk stratification by combining traditional clinicopathological parameters, determine how optimally utilized direct patient care. Pathologists clinicians caring for women need engage understand possibilities limitations new approach, because cancers anticipated become an essential part gynaecological pathology practice. This review will describe challenges in carcinoma classification, evolution technologies prognostically potential applications step precision medicine refining care individuals most common developed world. Copyright © 2018 Pathological Society Great Britain Ireland. Published John Wiley & Sons, Ltd.