Modulation of Protein–Protein Interactions with Small Organic Molecules

摘要: Many proteins exert their biological roles as components of complexes, and the functions are often determined by specific interactions with other proteins. Because central importance protein-protein for cellular processes, ability to interfere provides a powerful means influencing function selected within cell. Cell-permeable small organic modulators thus highly desirable tools both study physiological processes treatment numerous diseased states. Herein number that considered be pharmaceutical targets presented, which will familiarize reader strategies have been employed successful identification molecule these interactions. These encouraging examples suggest combined research efforts in areas functional proteomics, assay development, synthesis open up novel possibilities human diseases future.