A multidose package, course and method of treatment for delivering predetermined multiple doses of a pharmaceutical

作者: Mark J. Hutchings , Christiaan M. Van Niekerk

DOI:

关键词:

摘要: The invention provides: a multidose package containing an imiquimod formulation suitable for treating topical conditions such as actinic keratosis, superficial basal cell carcinoma and external genital warts, said comprising: a) dispensing aperture the from package; b) reservoir sufficient amount of to provide two or more doses; c) metered dosage means measuring predetermined dose formulation, comprising inlet outlet aperture; d) actuating operating that is delivered wherein dispensed without microbial other contamination degradation in reservoir; course treatment warts provision formulation' treatment; method with multiple doses characterised are provided by providing warts.

参考文章(17)
Vladimir Naddaka, Oded Arad, Shady Saeed, Eyal Klopfer, Stephen Cherkez, Imiquimod production process ,(2007)
Ido Yosha, Hila Tsahor, Tatiana Tikhonenko, Ronen Naim, Imiquimod cream formulation ,(2006)
Gregory R C O Riker Lab Nelson, Steven M C O Riker Labora Wick, Amit K C O Riker Laborat Mitra, Helen Jensen C O Riker Schultz, Stephen M C O Riker Labo Berge, Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo 4,5-C!quinolin-4-amine ,(1989)
Alexis S. Statham, Robert J. Nelson, Pharmaceutical creams with reduced imiquimod impurities ,(2010)
Mark Lebwohl, Scott Dinehart, David Whiting, Peter K Lee, Naji Tawfik, Joseph Jorizzo, James H Lee, Terry L Fox, Imiquimod 5% cream for the treatment of actinic keratosis: results from two phase III, randomized, double-blind, parallel group, vehicle-controlled trials Journal of the American Academy of Dermatology. ,vol. 50, pp. 714- 721 ,(2004) , 10.1016/J.JAAD.2003.12.010
John Geisse, Ivor Caro, Jane Lindholm, Loren Golitz, Patti Stampone, Mary Owens, Imiquimod 5% cream for the treatment of superficial basal cell carcinoma: results from two phase III, randomized, vehicle-controlled studies Journal of the American Academy of Dermatology. ,vol. 50, pp. 722- 733 ,(2004) , 10.1016/J.JAAD.2003.11.066