6',7'-dihydroxybergamottin, a cytochrome P450 inhibitor in grapefruit
作者： Patrick M. Woster , David J. Edwards
DOI:
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摘要: The present invention provides a composition and methods for inhibiting cytochrome P450 enzyme activity in particular, the of 3A sub-family enzymes, specifically, CYP3A4. 6',7'-dihydroxybergamottin, furanocoumarin, as compound primarily responsable inhibitory effects grapefruit juice on activity. also novel synthesis scheme 6',7'-dihydroxybergamottin.
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