Transthoracic drug delivery device
作者： Richard T. Choh , Stephen J. Forcucci , Robert Cafferata , Richard A. Gambale
DOI:
关键词:
摘要: The present invention provides a transthoracic drug delivery device (10) that utilizes pressure to determine the precise location of distal tip (18) tube (14) insure therapeutic substances are ejected into myocardium (4) and not dissipated in unintended tissue locations. In one embodiment comprises sensing (12) mounted parallel wherein tubes staggered so extends beyond (14). another embodiment, steerable syringe is provided multiple sites can be treated with substance only penetration heart. Once (28) penetrates left ventricle, its (32) deflected back toward endocardial surface (6) withdrawn proximally cause (4). deflectable adjusted different deflection angle rotated make available circular array points may accessed by syringe.
google.de 参考文章(112)
Peter J. Wilk, Coronary artery by-pass method and associated catheter ,(1992)
Steven Gitelis, Timothy R. Devine, Donald A. Randolph, Jodi L. Negri, Controlled dissolution pellet containing calcium sulfate ,(1996)
Fenella C. Raymond, Darrell C. Conklin, Paul O. Sheppard, Brigit Hansen, Susan D. Julien, Thomas R. Bukowski, Theresa A. Deisher, Fibroblast growth factor homologs ,(1997)
Jack E. Parr, Bernard F. Grisoni, Steve Gitelis, Timothy L. Harrison, Ben R. Shappley, Implantable bioresorbable string of calcium sulfate beads ,(1996)
Jeffrey L. Kraus, Linda T. Guthrie, Gary H. Miller, Guidewire assembly with steerable adjustable tip ,(1988)
Lindsay S. Machan, William L. Hunter, Compositions and methods for treating or preventing diseases of body passageways ,(2004)
James A. Nelson, Ascher Shmulewitz, John Burton, Apparatus for treating ischemic heart disease by providing transvenous myocardial perfusion Official Gazette of the United States Patent and Trademark Office Patents. ,vol. 1201, pp. 963- 964 ,(1997)
Olivier BERTRAND, Rosaire MONGRAIN, Jean-François TANGUAY, Luc BILODEAU, Radioactivity local delivery system ,(1997)
Richard L. Verrier, Method for transvenously accessing the pericardial space via the right auricle for medical procedures ,(1991)
SK Tam, W Gu, V Mahdavi, B Nadal-Ginard, None, Cardiac myocyte terminal differentiation. Potential for cardiac regeneration. Annals of the New York Academy of Sciences. ,vol. 752, pp. 72- 79 ,(1995) , 10.1111/J.1749-6632.1995.TB17407.X