Bax345/BLyS: A novel, completely human fusion protein targeting malignant B cells and delivering a unique mitochondrial toxin
作者： Mi-Ae Lyu , Lawrence H. Cheung , Walter N. Hittelman , Yuying Liu , John W. Marks
DOI: 10.1016/J.CANLET.2012.02.029
关键词:
摘要: We generated a fusion protein Bax345/BLyS containing the truncated form of Bax (Bax345) at N-terminus followed by 218 linker to B lymphocyte stimulator (BLyS). was cytotoxic panel diffuse large cell lymphoma and mantle lines expressing BLyS receptors. Specific delivery malignant cells drove into apoptosis mitochondrial dysfunction treatment with induced down-regulation Mcl-1, X-IAP, survivin. represents new class targeted therapeutic agents unique mechanism action may have potential for cells.
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