Emergency admissions for upper gastrointestinal disease and their relation to NSAID use

摘要: Background: There are considerable variations in estimates of the number emergency upper gastrointestinal admissions per annum which attributable to nonsteroidal anti-inflammatory drug (NSAID) use. Aim: To obtain a more accurate estimate these UK. Methods: A retrospective survey case notes all for disease (‘Cases’) two English District General Hospitals with combined catchment population 550000. Records community deaths attributed diagnoses (with same ICD codes) were also surveyed. Matched controls identified from not caused by diagnoses. The proportions patients taking NSAIDs on admission hospital (or at time death home) and outcome following analysed. Results: 620 matched 460 controls. Cases likely be NSAID users than Controls (31% vs. 16%, OR 2.4, 95% CI: 1.8, 3.3; P<0.001). Case use was higher females increasing age. As severity mode presentation worsened, probability increased (e.g. relative peptic pain 1.9, perforation 5.9). Blood transfusion requirements significantly (P<0.0001) NSAIDs, although did influence mortality. Extrapolation data indicate that there 65000 UK; 12000 (including 2230 deaths) use. further 330 occur community. Conclusions: is strong association between propensity admission; associated significant morbidity mortality each year UK.