Spinal cord regeneration: Lessons for mammals from non-mammalian vertebrates

摘要: Unlike mammals, regenerative model organisms such as amphibians and fish are capable of spinal cord regeneration after injury. Certain key differences between nonregenerative have been suggested involved in promoting this process, the capacity for neurogenesis axonal regeneration, which appear to be facilitated by favorable astroglial, inflammatory immune responses. These traits provide a regenerative-permissive environment that mammalian appears lacking. Evidence nonpermissive mammals is given fact they possess neural stem/progenitor cells, transplanted into permissive environments able give rise new neurons, whereas unable do so. We discuss comparing what happens with each organism, aiming describe identify allow regeneration. This comparison should lead us toward finding how promote