Effects of multiple intravitreal anti-VEGF injections on retinal nerve fiber layer and intraocular pressure: a comparative clinical study.

摘要: AIM To determine the effect of multiple injections ranibizumab or bevacizumab on retinal nerve fiber layer (RNFL) and intraocular pressure (IOP) in patients with age-related macular degeneration (AMD). METHODS This retrospective study includes 35 eyes treated intravitreal (IVB, 1.25mg/0.05mL) 30 (IVR, 0.5mg/0.05mL) who had Fast RNFL analysis (Stratus™); IOP measurements were taken minutes 24 hours after each injection. RESULTS The mean ages 68.0±7.5 69.1±7.7 years IVR IVB groups, respectively (P=0.55). They underwent (6.3±1.9) (5.1±1.3) (P=0.07) over (13.6±2.1) (14.05±2.6) months (P=0.45) respectively. Changes overall temporal thickness IVR-treated (105.3±6.9µm 74.4±11.2µm) not different from those untreated group (104.6± 8.4µm 75.1±12.6µm) (P=0.57 P=0.41, respectively). Similarly, IVB-treated (105.8±8.1µm 74.5±11.8µm) (104.6±8µm 74.8±12.9µm) (P=0.42 P=0.80, frequencies rise (P=0.60) changes baseline (P=0.16) comparable between groups. CONCLUSION Repeated injection does seem have adverse effects wet AMD patients.