The role of the ubiquitin–proteasome system in kidney diseases

摘要: Proteins in mammalian cells are continually being degraded and synthesized. Protein degradation via the ubiquitin–proteasome system (UPS) is major pathway for non-lysosomal proteolysis of intracellular proteins plays important roles a variety fundamental cellular processes such as regulation cell cycle progression, differentiation, apoptosis, sodium channel function, modulation inflammatory responses. The central element this covalent linkage ubiquitins to targeted proteins, which then recognized by 26S proteasome composed adenosine triphosphate-dependent, multi-catalytic proteases. Damaged or misfolded well regulatory that control many critical functions, among targets process. Consequently, aberration leads dysregulation homeostasis development diseases. Based on findings, it not surprising abnormalities also associated with pathogenesis kidney In review, I discuss (1) basic mechanism UPS, (2) association between diseases UPS. Diverse UPS implicated diseases, further studies may reveal new strategies overcoming