Genetic polymorphisms in folate metabolism and the risk of stomach cancer

摘要: Folate deficiency has been implicated in the etiology of stomach cancer through abnormal DNA methylation and disrupted synthesis repair. Enzyme-coding genes involved folate metabolism are often polymorphic. In a population-based study 305 cases 427 controls Warsaw, Poland, we evaluated risk relation to polymorphisms folate-metabolizing genes, including MTHFR (Ex5+79C>T Ex8−62A>C), MTR (Ex26−20A>G), MTRR (Ex2−64A>G, Ex5+123C>T, Ex15+572C>T, Ex15−405A>T, Ex9−85C>T, Ex15−526G>A, Ex14+14C>T). Polymorphisms gene were not associated with risk. No notable effect was found for or either, although Ex26−20 A>G Ex5+123C>T borderline increased (MTR Ex26−20A>G, AG/GG versus AA: odds ratio, 1.35; 95% confidence interval, 0.96-1.90; CT/TT CC: 1.30; 0.93-1.82). We did find significant interactions between MTHFR, MTR, dietary alcohol consumption. Our identify strong genetic determinants pathway (Cancer Epidemiol Biomarkers Prev 2007;16(1):115–21)