Oncogenes and their Encoded Products as Targets for Cancer Therapy
作者： Doris L. Slate
DOI: 10.1007/978-94-009-2526-7_13
关键词:
摘要: Recent advances in the biochemical and molecular understanding of tumor cell function are providing new insights into alterations growth regulation which underlie aberrant proliferation seen neoplastic disease. Perhaps best example these comes from “rediscovery” oncogenes; genes represent normal cellular DNA sequences (c-onc or proto-onc genes) which, through particular activating events carcinogenesis, become “oncogenic” capable triggering malignant transformation (reviewed Varmus (85)). Many had earlier been described as transforming (v-onc) RNA viruses (5). Even though exact details oncogene have yet to be fully defined, early studies begun suggest new, unifying themes for abnormal control (54, 86).
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sci-hub.st 参考文章(87)
Tony Hunter, J.A. Cooper, Role of tyrosine phosphorylation in malignant transformation by viruses and in cellular growth control. Progress in Nucleic Acid Research and Molecular Biology. ,vol. 29, pp. 221- 232 ,(1983) , 10.1016/S0079-6603(08)60450-X
R. J. Muschel, L. A. Liotta, J. E. Williams, D. R. Lowy, Harvey ras induction of metastatic potential depends upon oncogene activation and the type of recipient cell. American Journal of Pathology. ,vol. 121, pp. 1- 8 ,(1985)
I. Lax, R. Kris, I. Sasson, A. Ullrich, M.J. Hayman, H. Beug, J. Schlessinger, Activation of c-erbB in avian leukosis virus-induced erythroblastosis leads to the expression of a truncated EGF receptor kinase. The EMBO Journal. ,vol. 4, pp. 3179- 3182 ,(1985) , 10.1002/J.1460-2075.1985.TB04062.X
M Nishizawa, B J Mayer, T Takeya, T Yamamoto, K Toyoshima, H Hanafusa, S Kawai, Two independent mutations are required for temperature-sensitive cell transformation by a Rous sarcoma virus temperature-sensitive mutant. Journal of Virology. ,vol. 56, pp. 743- 749 ,(1985) , 10.1128/JVI.56.3.743-749.1985
S Braun, W E Raymond, E Racker, Synthetic tyrosine polymers as substrates and inhibitors of tyrosine-specific protein kinases. Journal of Biological Chemistry. ,vol. 259, pp. 2051- 2054 ,(1984) , 10.1016/S0021-9258(17)43311-4
T W Wong, A R Goldberg, In vitro phosphorylation of angiotensin analogs by tyrosyl protein kinases. Journal of Biological Chemistry. ,vol. 258, pp. 1022- 1025 ,(1983) , 10.1016/S0021-9258(18)33153-3
M J Ellison, R J Kelleher, A Rich, Thermal regulation of beta-galactosidase synthesis using anti-sense RNA directed against the coding portion of the mRNA. Journal of Biological Chemistry. ,vol. 260, pp. 9085- 9087 ,(1985) , 10.1016/S0021-9258(17)39332-8
A. Bernstein, Robin Weiss, RNA tumor viruses University of California, San Francisco. Archives and Special Collections. Harold E. Varmus Papers. ,(1982)
J A Cooper, T Hunter, Identification and characterization of cellular targets for tyrosine protein kinases. Journal of Biological Chemistry. ,vol. 258, pp. 1108- 1115 ,(1983) , 10.1016/S0021-9258(18)33165-X
Peter J. Fischinger, Vincent T. DeVita, Governance of Science at the National Cancer Institute: Perceptions and Opportunities in Oncogene Research Cancer Research. ,vol. 44, pp. 4693- 4696 ,(1984)