The effect of antigen on antibodies: recent studies.
作者： Henry Metzger
DOI: 10.1007/978-1-4757-0779-3_4
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摘要: In 1972–1973 I reviewed what was known about the effect of antigen on properties antibodies (Metzger, 1974). Several possibilities which had been suggested by various investigators were considered. According to allosteric model, virtue its chemical structure induces conformational changes distal combining site. These would in turn lead molecule (receptor) activated antigen-antibody complex. distortive topological distribution antigenic determinants leads a distortion semirigid antibody molecule, resulting effects similar those postulated for model. Finally simple associative model action Here polymerization multideterminant be critical and perhaps sufficient role played antigen. concluded that “... weight evidence speaks against both models action. We are left with know no data inconsistent this ... there is much favor it.”
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