Tweaking dendrimers and dendritic nanoparticles for controlled nano-bio interactions: potential nanocarriers for improved cancer targeting.

摘要: Nanoparticles have shown great promise in the treatment of cancer, with a demonstrated potential targeted drug delivery. Among myriad nanocarriers that been recently developed, dendrimers attracted deal scientific interests due to their unique chemical and structural properties allow for precise engineering characteristics. Despite this, clinical translation has hindered drawbacks, such as scale-up issues, rapid systemic elimination, inefficient tumor accumulation limited loading. In order overcome these limitations, series reengineered introduced using various approaches, including: (i) modifications structure surfaces; (ii) integration linear polymers (iii) hybridization other types nanocarriers. Chemical surface tailored improve pharmacokinetics tissue permeation. Copolymerization dendritic resulted amphiphilic copolymers self-assembly capabilities improved loading efficiencies. Hybridization integrates advantageous characteristics both systems, which includes prolonged plasma circulation times enhanced targeting. This review provides comprehensive summary newly emerging delivery systems involve reengineering an effort precisely control nano-bio interactions, mitigating inherent weaknesses.