Distinct signatures of dental plaque metabolic byproducts dictated by periodontal inflammatory status

摘要: Onset of chronic periodontitis is associated with an aberrant polymicrobial community, termed dysbiosis. Findings regarding its etiology obtained using high-throughput sequencing technique suggested that dysbiosis holds a conserved metabolic signature as emergent property. The purpose this study was to identify robust biomarkers for periodontal inflammation severity. Furthermore, we investigated disease-associated signatures microbiota salivary metabolomics approach. Whole saliva samples were from adult subjects before and after removal supragingival plaque (debridement). Periodontal inflamed surface area (PISA) employed indicator inflammatory status. Based on multivariate analyses pre-debridement data, found metabolites higher PISA included cadaverine hydrocinnamate, while uric acid ethanolamine lower PISA. Next, focused dental byproducts by selecting significantly decreased following debridement. Metabolite set enrichment analysis revealed polyamine metabolism, arginine proline butyric lysine degradation distinctive in the high group, which may be related communities. Collectively, our findings identified potential status also provide insight into dysbiotic