Anti-tumor medicament based on alpha ketoglutaric acid and derivatives thereof

摘要: The invention belongs to the technical field of biomedicine and relates an anti-tumor medicament based on alpha ketoglutaric acid derivatives thereof. comprise various ester derivatives, amide ether derivatives; comprises chemical analogues results in-vitro experiments indicate that mutation isocitrate dehydrogenase in gliomas loss enzyme activities, capable growing cells is obvious reduced, levels anaerobic inductor factors inducing tumors promoting growth are obviously improved, phenomenon can be reversed by exogenously replenishing absorbable acid. Therefore, compound used for treating gliomas, pancreatic cancers, breast liver lung gastric colorectal colon cancer melanomas.