作者: Susan A. Treloar , Nicholas G. Martin , Lorraine Dennerstein , Beverley Raphael , Andrew C. Heath
DOI: 10.1016/S0002-9378(11)91632-9
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摘要: Objective: We hypothesized that genetic influences act on "liability" to hysterectomy, secular might differentially affect relative importance of and environmental influences, the sources could be identified from reported risk factors. Study Design: Hysterectomy data an Australia-wide volunteer sample female adult monozygotic dizygotic twins are reported. In 1980 through 1982 a mailed questionnaire was completed by 1232 twin pairs 751 (3966 women) Australian Twin Register (wave 1). The same were surveyed 8 years later 2). Results: A total 366 had undergone hysterectomy wave 1 further 198 at 2. twin-pair correlations for liability (0.61 ± 0.06 0.20 0.11 dizygotic) 2 (0.65 0.05 0.32 0.09 monozygotic) indicated substantial contribution. Reported factors accounted only 15% variance. Conclusion: Genetic stable across birth cohorts, but important influence yet identified.