Phosphatidic acid phosphohydrolase in the regulation of inflammatory signaling.

摘要: Since the cloning and characterization of PAP-1 by Carman’s group, a preponderance new information has emerged pertaining to molecular function enzyme its physiological in lipid metabolism (Carman et al., 2006; Donkor 2007). As consequence this development, lipin research have informed us further regarding adipose tissue development Reue 2008). In recent years, field inflammatory signaling undergone great expansion come identify wide variety protein metabolic mediators, including as well PLD, PKC, PLC DAG. The focus review was summarize experimental evidence supporting role for signaling, which is summarized Scheme 2 (Grkovich Further clarification needed precise functions downstream targets DAG forming enzymes, such PLD/PAP-1 PLC, supports both participants different systems. Clarification these regulatory questions should lead more complete understanding while helping future pharmacological targets. Scheme 2 Role TLR-4 activation eicosanoid macrophages. Adapted from 2008). Summary LIST OF POSSIBLE MAJOR TOPICS Inlfammatory signaling Lipopolysaccharide Phosphatidic acid phosphohydrolase 1 Lipin Diacylglycerol Group IVA Phospholipase A2 Cyclooxygenase 2 Phospholipase C Phospholipase D Toll-like recptor 4 Lipid signaling Phosphatidic acid Triacylglycerol Phospholipid NF kappaB Acknowledgments Support provided NIH grant GM64611.