The Effects of Prolyl Oligopeptidase Inhibition in α-Synuclein Based Mouse Models of Parkinson's Disease
作者： Mari Savolainen
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摘要: … In the first part, direct protein-protein interaction between PREP and aSyn … Micro-scale thermophoresis mTOR … Factors that enhance the aggregation process are written in green. Two …
参考文章(312)
Janetta G. Culvenor, Catriona A. McLean, Sally Cutt, Bruce C.V. Campbell, Fran Maher, Pekka Jäkälä, Tobias Hartmann, Konrad Beyreuther, Colin L. Masters, Qiao-Xin Li, Non-Aβ Component of Alzheimer's Disease Amyloid (NAC) Revisited: NAC and α-Synuclein Are Not Associated with Aβ Amyloid American Journal of Pathology. ,vol. 155, pp. 1173- 1181 ,(1999) , 10.1016/S0002-9440(10)65220-0
E Masliah, M Sundsmo, A Takeda, M Mallory, W Honer, L Hansen, Abnormal accumulation of NACP/alpha-synuclein in neurodegenerative disorders American Journal of Pathology. ,vol. 152, pp. 367- 372 ,(1998)
Poul H. JENSEN, Peter HØJRUP, Henrik HAGER, Morten S. NIELSEN, Linda JACOBSEN, Ole F. OLESEN, Jørgen GLIEMANN, Ross JAKES, Binding of Abeta to alpha- and beta-synucleins: identification of segments in alpha-synuclein/NAC precursor that bind Abeta and NAC. Biochemical Journal. ,vol. 323, pp. 539- 546 ,(1997) , 10.1042/BJ3230539
Yoshiyuki Shishido, Masayoshi Furushiro, Shuichi Tanabe, Akira Taniguchi, Shusuke Hashimoto, Teruo Yokokura, Shigenobu Shibata, Tsuneyuki Yamamoto, Shigenori Watanabe, Effect of ZTTA, a prolyl endopeptidase inhibitor, on memory impairment in a passive avoidance test of rats with basal forebrain lesions Pharmaceutical Research. ,vol. 15, pp. 1907- 1910 ,(1998) , 10.1023/A:1011922526538
Kelly Del Tredici, Udo Rüb, Rob A.I. de Vos, Jürgen R.E. Bohl, Heiko Braak, Where does Parkinson disease pathology begin in the brain Journal of Neuropathology and Experimental Neurology. ,vol. 61, pp. 413- 426 ,(2002) , 10.1093/JNEN/61.5.413
Masato Hasegawa, Hideo Fujiwara, Takashi Nonaka, Koichi Wakabayashi, Hitoshi Takahashi, Virginia M.-Y. Lee, John Q. Trojanowski, David Mann, Takeshi Iwatsubo, Phosphorylated α-Synuclein Is Ubiquitinated in α-Synucleinopathy Lesions Journal of Biological Chemistry. ,vol. 277, pp. 49071- 49076 ,(2002) , 10.1074/JBC.M208046200
TT Myöhänen, MJ Hannula, R Van Elzen, M Gerard, P Van Der Veken, JA García-Horsman, V Baekelandt, PT Männistö, AM Lambeir, A prolyl oligopeptidase inhibitor, KYP-2047, reduces α-synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease. British Journal of Pharmacology. ,vol. 166, pp. 1097- 1113 ,(2012) , 10.1111/J.1476-5381.2012.01846.X
Simone Engelender, Zachary Kaminsky, Xin Guo, Alan H. Sharp, Ravi K. Amaravi, John J. Kleiderlein, Russell L. Margolis, Juan C. Troncoso, Anthony A. Lanahan, Paul F. Worley, Valina L. Dawson, Ted M. Dawson, Christopher A. Ross, Synphilin-1 associates with α-synuclein and promotes the formation of cytosolic inclusions Nature Genetics. ,vol. 22, pp. 110- 114 ,(1999) , 10.1038/8820
Hardy J. Rideout, Kristin E. Larsen, David Sulzer, Leonidas Stefanis, Proteasomal inhibition leads to formation of ubiquitin/α-synuclein-immunoreactive inclusions in PC12 cells Journal of Neurochemistry. ,vol. 78, pp. 899- 908 ,(2001) , 10.1046/J.1471-4159.2001.00474.X
Hideo Fujiwara, Masato Hasegawa, Naoshi Dohmae, Akiko Kawashima, Eliezer Masliah, Matthew S. Goldberg, Jie Shen, Koji Takio, Takeshi Iwatsubo, |[alpha]|-Synuclein is phosphorylated in synucleinopathy lesions Nature Cell Biology. ,vol. 4, pp. 160- 164 ,(2002) , 10.1038/NCB748