Preparation of polyelectrolyte multilayer coated microbubbles for use as ultrasound contrast agent.
作者： Zhan-wen Xing , Heng-te Ke , Shao-qin Liu , Zhi-fei Dai , Jin-rui Wang
DOI: 10.1016/S1001-9294(09)60020-1
关键词:
摘要: Objective To prepare and characterize polyelectrolyte multilayer film coated microbubbles for use as ultrasound contrast agent (UCA) evaluate its effects in ultrasonic imaging on normal rabbit's liver parenchyma. Methods Perfluorocarbon (PFC)-containing (ST68-PFC) were prepared by sonication based surfactant (Span 60 Tween 80). Subsequently, the resulting ST68-PFC using oppositely charged polyelectrolytes microbubble-templated layer-by-layer self-assembly technique via electrostatic interaction. The enhancement parenchyma assessed. Results obtained exhibited a narrow size distribution. successfully assembled onto surface of microbubbles. In vivo experiment showed that UCA effectively enhanced Conclusion novel with multilayer, when enabled more function, has no obvious difference compared pre-modified polymers chemically active groups (such amino group carboxyl group) can be used outermost layer attachment targeting ligands microbubbles, allowing selective to combine desired sites.
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