Transcriptional regulation in the context of chromatin structure.

摘要: A wide variety of histone-like proteins can be assembled into nucleosomal structures. Core and linker histone variants, the histone-fold winged-helix families all contribute to local differentiation functional chromosomal domains. It is very difficult disrupt core interactions within a nucleosome in vivo. Histones H3 H4 do not exchange out chromatin outside S-phase. H2A H2B chromatin, but so predominantly during transcription. This confers stability on cell cycle. Linker histones have much less stable association with DNA, allowing for reversible activation distinct feature DNA exposure surface nucleosome. One side occluded surface, other exposed potentially accessible regulatory proteins. major contributory factor specialization capacity target modification disruption.