An analysis of predictors of long-term cadaveric renal allograft survival.

摘要: To determine factors predictive of long-term graft function in patients treated prophylactically with an antilymphocyte antibody, 670 first cadaveric adult renal transplant procedures performed between 1985 and 1991 were reviewed. The actuarial 1- 5-year patient survival this group was 95% 87% respectively, 84% 70% respectively. final analysis based on a study 635 which excluded 28 who lost grafts to early technical failures 8 not induced preparation. Multivariate showed that lower delayed (p=0.0001), those had acute rejection episode the 6 months post-transplant recipients greater than 55 years age at time highly sensitized (p=0.0331) and, finally, received from older donor (p=0.044). 209 16% 425 (62% vs. 78% respectively 5 years). One or more episodes (329 patients) reduced by 13% compared did have (67% 80% 219 free 85% 60% 122 (p<0.0005). Recipient over because death functioning graft. other two independent variables, degree sensitization age, weaker effect increasing risk ratio 1.013 for 1.104 age. There only minor interaction activity. 52% whereas 42% no (p<0.05). HLA matching outcome, but interact 57% 2 fewer BDR mismatches as 44% (p<0.0001). Serum creatinine dependent variable influenced survival. Patients serum ≤200 μmol/1 (2.27 mg%) 27% increase impaired (86% 59% post-transplant)