Allergen-specific immunotherapy for patients with atopic dermatitis sensitized to animal dander.

摘要: INTRODUCTION Atopic dermatitis (AD) is a chronic inflammatory skin disease, and AD patients are commonly sensitized to house dust mite (HDM). Of the several treatment options available, allergen-specific immunotherapy (AIT) has been recognized as an effective modality that directed toward immunoglobulin E (IgE)-mediated nature of AD, subcutaneous administration using HDM most used for AIT in AD. For animal (dog or cat) dander, may not be easy, especially when avoiding allergen possible. METHODS This study enrolled with who were cat and/or dog dander underwent (n = 19). Patients' medical information was obtained, including past history, duration AIT, progress treatment. Also, specific IgE levels IgG4 measured before after AIT. RESULTS A total 19 dander. The consisted 4 males 15 females average age 31.74 ± 9.71. Only two had only, other 17 one more concomitant allergic diseases, such rhinitis, asthma, conjunctivitis. Seven HDMs only ranged from 2 58 months. symptoms well-controlled, requiring topical oral antihistamines. One patient required systemic cyclosporine, but low dose (25 mg/day). decreased (P = .005) showed tendency increasing No adverse events observed these patients. CONCLUSION Although larger number longer follow-up period needed precisely assess efficacy, option patients, severe respiratory comorbidities cannot completely avoid exposure