Peptide and peptide-inspired checkpoint inhibitors: Protein fragments to cancer immunotherapy

摘要: Abstract Immune system regained the attention of oncologists and has entered mainstream for cancer therapy since discovery checkpoint antibodies targeting CTLA4 PD-1 pathways. Efficacy in only a subset patient population observed with current inhibitors is considered as one major limitations this approach. A number strategies including combination newer tumor-targeted agents well blocking proteins alternate approaches are being evaluated to overcome restricted efficacy. This review provides an overview protein superfamily nature interacting interface receptors ligands, explores potential advantages peptide or peptide-based inhibitor approach that mimic native interaction interface. Additionally, covers rationale peptides/peptidomimetics discovered against various proteins, transformation few such peptides peptide-inspired orally bioavailable immunotherapy.