Immunosuppression of Fertility by LDH-C4

作者: Erwin Goldberg , Joyce A. Shelton

DOI: 10.1007/978-1-4684-5140-5_26

关键词:

摘要: The natural response of the immune system to foreign proteins can be exploited in development a vaccine for control fertility. Potential target antigens such include those that are found specifically on surface sperm and absent from somatic tissues (reviewed by Aitken, 1982, Goldberg, 1983, Anderson Alexander, 1983). Such uniquely suited incorporation into may applicable both male female use. They do not appear until spermatogenesis begins, which is after has already become tolerant “self-antigens”. Even they appear, isolated blood-testes barrier. at all tissues. Thus these provoke antibody formation either males or females. Furthermore, would have advantage over currently available contraceptive methodologies interfering with hormonal metabolic functions.

参考文章(38)
W.D. Musick, M.G. Rossmann, The tentative amino acid sequencing of lactate dehydrogenase C4 by X-ray diffraction analysis. Journal of Biological Chemistry. ,vol. 254, pp. 7621- 7623 ,(1979) , 10.1016/S0021-9258(18)35990-8
Thomas E. Wheat, Erwin Goldberg, ISOLATION OF THE SPERM SPECIFIC LACTATE DEHYDROGENASE FROM MOUSE, RABBIT AND HUMAN TESTIS AND HUMAN SPERMATOZOA Immunological Influence on Human Fertility#R##N#Proceedings of the Workshop on Fertility in Human Reproduction. pp. 221- 227 ,(1977) , 10.1016/B978-0-7295-0006-7.50028-8
S. L. Jeffcoate, Merton Sandler, Progress towards a male contraceptive Chichester Eng. John Wiley 1982.. ,(1982)
Thomas G. Wegmann, Thomas J. Gill, Immunology of reproduction Oxford University Press. ,(1983)
Gerald I. Zatuchni, Miriam H. Labbok, John J. Sciarra, Research frontiers in fertility regulation Hagerstown Md. Harper and Row 1980.. ,(1980)
John G. Scandalios, Mario C. Rattazzi, Gregory S. Whitt, Isozymes : current topics in biological and medical research Liss. ,(1977)
W. R. Jones, Immunological Factors in Male and Female Infertility Immunological Aspects of Reproduction and Fertility Control. pp. 105- 140 ,(1980) , 10.1007/978-94-011-8039-9_5
S S Li, R J Feldmann, M Okabe, Y C Pan, Molecular features and immunological properties of lactate dehydrogenase C4 isozymes from mouse and rat testes. Journal of Biological Chemistry. ,vol. 258, pp. 7017- 7028 ,(1983) , 10.1016/S0021-9258(18)32326-3
W.D.L. Musick, M.G. Rossmann, The structure of mouse testicular lactate dehydrogenase isoenzyme C4 at 2.9 A resolution. Journal of Biological Chemistry. ,vol. 254, pp. 7611- 7620 ,(1978) , 10.2210/PDB1LDX/PDB