Changes in active and inactive renin throughout pregnancy.

摘要: In the first trimester of pregnancy, inactive renin in plasma rapidly increases (to 5 times average concentration nonpregnant controls), then declines slowly until midpregnancy, and falls quickly to normal range after delivery. Inactive has same large apparent molecular weight pregnancy as control plasma. Amniotic fluid contains very high levels renin; its mobility on Sephadex G-100 is that renin, but a lower indicated by delayed elution amniotic from Sephacryl S-200. This anomalous behavior probably responsible for different estimates previously reported. The active modestly increased trimester, declining gradually term, falling Although PRA early involves an increase angiotensinogen appears play more important part sustaining late pregnancy. te larger than Gross changes sodium intake during result concentrations parallel those observed controls. These responses suggest kidneys are source altered do not exclude contribution other sources.