Enhanced antifungal activity by disinfected titanium dioxide nanotubes via reduced nano-adhesion bonds
作者： Alan Escamilla , Nicola Nedev , Ernesto Beltrán-Partida , Benjamín Valdez-Salas , Mario Curiel-Álvarez
DOI: 10.1016/J.MSEC.2017.02.153
关键词:
摘要: We have provided evidence that the beneficial effect of super-oxidized water (SOW) disinfected Ti6Al4V-TiO2 nanotubes (NTs) can reduce bacterial adhesion and biofilm formation. However, need antifungal nanostructured surfaces with osteoactive capabilities is an important goal has been arising for dental implants (DI) applications. Thus, in present study we isolated tested effects Candida albicans (C. albicans) on disinfected, wetter nanoroughness NTs compared to a non-modified control. Moreover, elucidated part fungal mechanism by studying relating mycotic kinetics formation nanoadhesion bonds among experimental materials, gain new insight fungal-material-interface. Similarly, initial behavior human alveolar bone osteoblasts (HAOb) was microscopically evaluated. significantly reduced yeasts viability non-outcomes than surface. Cross-sectioning cells revealed promoted nano-contact superior spread control alloy interface; meanwhile evidenced decreased tendency along time; suggesting, down-regulation morphology SOW treatment. Importantly, performance HAOb demonstrated strikingly anchorage filopodia increased vital cell SOW. The proposes treatment as active protocol synthesis disinfection potent capability, acting reduction nano-adhesion at surface-fungal opening up novel route investigation mycotic-adhesion processes nanoscale
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