Synthesis, characterization, mucoadhesion and biocompatibility of thiolated carboxymethyl dextran-cysteine conjugate.
作者： G. Shahnaz , G. Perera , D. Sakloetsakun , D. Rahmat , A. Bernkop-Schnürch
DOI: 10.1016/J.JCONREL.2010.01.033
关键词:
摘要: Abstract This study was aimed at improving the mucoadhesive properties of carboxymethyl dextran by covalent attachment cysteine. Mediated a carbodiimide, l -cysteine covalently attached to polymer. The resulting CMD–cysteine conjugate (CMD-273 conjugate) displayed 273 ± 20 μmol thiol groups per gram polymer (mean ± S.D.; n = 3). Within 2 h viscosity an aqueous mucus/CMD-273 mixture pH 7.4 increased 37 °C more than 85% compared mucus/carboxymethyl indicating enlarged interactions between mucus and thiolated Due immobilization cysteine, swelling velocity significantly accelerated (p
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