Choline transporter-like proteins CTLs/SLC44 family as a novel molecular target for cancer therapy

摘要: Choline is essential for the synthesis of major membrane phospholipid phosphatidylcholine (PC), methyl donor betaine and neurotransmitter acetylcholine (ACh). Elevated levels choline up-regulated kinase activity have been detected in various cancers. Thus, intracellular accumulation through transporters rate-limiting step metabolism a prerequisite cancer cell proliferation. Previous studies demonstrated abnormalities uptake cells using imaging with positron emission tomography (PET) magnetic resonance spectroscopy (MRS). The aberrant strongly correlated their malignant progression. Using quantitative real-time PCR, mRNA expression was measured, it found that transporter-like proteins CTLs/SLC44 family are highly expressed lines. CTLs associated viability, functional inhibition could promote apoptotic death. Furthermore, non-neuronal cholinergic systems include CTLs-mediated transport proliferation promotes death colon cancer, small lung human leukemic T-cells. identification this new system provides potential target therapy. Copyright © 2014 John Wiley & Sons, Ltd.