Effect of flumazenil on GABAA receptors in isolated rat hippocampal neurons.
作者： Michel Weiss , Denis Tikhonov , Svetlana Buldakova
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摘要: Using whole cell patch-clamp recordings from pyramidal cells acutely dissociated rat hippocampal slices, Ro-15 1788 (flumazenil, FLU) was shown to enhance the GABAA-receptor mediated currents evoked by application of gamma-aminobutyric acid (GABA) and antagonize enhancing effect benzodiazepine agonist flurazepam (FZP) on GABAA response. Both FLU FZP increased peak steady-state components responses accelerated current decay. This suggests that both agents act via a common mechanism GABA transmission. It is concluded possesses high affinity for binding site, but low efficacy GABAA-benzodiazepine receptor. acts as partial receptors.
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