The effect of porosity of a biphasic ceramic scaffold on human skeletal stem cell growth and differentiation in vivo
作者： Alexander Aarvold , James O. Smith , Edward R. Tayton , Stuart A. Lanham , Julian B. Chaudhuri
DOI: 10.1002/JBM.A.34646
关键词:
摘要: Skeletal stem cell (SSC) growth on a novel porous HA/TCP scaffold has been investigated in vivo. The effect of porosity osteogenic differentiation was assessed by comparing two groups scaffolds with differing but controlled pore size. Histology, microCT, scanning electron microscopy, and biochemical analysis were used to assess SSC proliferation differentiation. 45 pores per inch (ppi) demonstrated greater increase density than the 30 ppi following vivo culture, reduction dimensions channels higher observed, indicating generation new tissue within pores. All supported augmented ALP specific activity enhanced compared scaffold. These studies demonstrate importance design impact therein for engineering application.
core.ac.uk
bath.ac.uk
sci-hub.se 参考文章(16)
Y.H. Hsu, I.G. Turner, A.W. Miles, Fabrication of Porous Calcium Phosphate Bioceramics as Synthetic Cortical Bone Graft Key Engineering Materials. ,vol. 284-286, pp. 305- 308 ,(2005) , 10.4028/WWW.SCIENTIFIC.NET/KEM.284-286.305
Pamela Habibovic, Klaas de Groot, Osteoinductive biomaterials--properties and relevance in bone repair. Journal of Tissue Engineering and Regenerative Medicine. ,vol. 1, pp. 25- 32 ,(2007) , 10.1002/TERM.5
Shunsuke Fujibayashi, Masashi Neo, Hyun-Min Kim, Tadashi Kokubo, Takashi Nakamura, Osteoinduction of porous bioactive titanium metal. Biomaterials. ,vol. 25, pp. 443- 450 ,(2004) , 10.1016/S0142-9612(03)00551-9
R S Tare, J Kanczler, A Aarvold, A M H Jones, D G Dunlop, R O C Oreffo, Skeletal stem cells and bone regeneration: translational strategies from bench to clinic. Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. ,vol. 224, pp. 1455- 1470 ,(2010) , 10.1243/09544119JEIM750
Ugo Ripamonti, Jean Crooks, Lerato Khoali, Laura Roden, The induction of bone formation by coral-derived calcium carbonate/hydroxyapatite constructs. Biomaterials. ,vol. 30, pp. 1428- 1439 ,(2009) , 10.1016/J.BIOMATERIALS.2008.10.065
Y.H. Hsu, I.G. Turner, A.W. Miles, The Effect of Slip Loading on the Properties of Porous Calcium Phosphate Bioceramics Key Engineering Materials. pp. 19- 22 ,(2007) , 10.4028/WWW.SCIENTIFIC.NET/KEM.361-363.19
Caixia Xu, Peiqiang Su, Xiaofeng Chen, Yongchun Meng, Weihua Yu, Andy Peng Xiang, Yingjun Wang, Biocompatibility and osteogenesis of biomimetic Bioglass-Collagen-Phosphatidylserine composite scaffolds for bone tissue engineering Biomaterials. ,vol. 32, pp. 1051- 1058 ,(2011) , 10.1016/J.BIOMATERIALS.2010.09.068
Janos M. Kanczler, Patrick J. Ginty, John J.A. Barry, Nicholas M.P. Clarke, Steve M. Howdle, Kevin M. Shakesheff, Richard O.C. Oreffo, The effect of mesenchymal populations and vascular endothelial growth factor delivered from biodegradable polymer scaffolds on bone formation Biomaterials. ,vol. 29, pp. 1892- 1900 ,(2008) , 10.1016/J.BIOMATERIALS.2007.12.031
Huipin Yuan, Zongjian Yang, Joost D. de Bruijn, Klaas de Groot, Xingdong Zhang, Material-dependent bone induction by calcium phosphate ceramics: a 2.5-year study in dog Biomaterials. ,vol. 22, pp. 2617- 2623 ,(2001) , 10.1016/S0142-9612(00)00450-6
Dietmar Werner Hutmacher, Jan Thorsten Schantz, Christopher Xu Fu Lam, Kim Cheng Tan, Thiam Chye Lim, State of the art and future directions of scaffold-based bone engineering from a biomaterials perspective. Journal of Tissue Engineering and Regenerative Medicine. ,vol. 1, pp. 245- 260 ,(2007) , 10.1002/TERM.24