Epidemiological studies of esophageal cancer in the era of genome-wide association studies
作者： An-Hui Wang , Yuan Liu , Bo Wang , Yi-Xuan He , Ye-Xian Fang
关键词:
摘要: Esophageal cancer (EC) caused about 395000 deaths in 2010. China has the most cases of EC and is fourth leading cause death China. squamous cell carcinoma (ESCC) predominant histologic type (90%-95%), while incidence esophageal adenocarcinoma (EAC) remains extremely low Traditional epidemiological studies have revealed that environmental carcinogens are risk factors for EC. Molecular susceptibility to influenced by both genetic factors. Of all EC, some associated with ESCC others EAC. However, details mechanisms involved process unclear. The advanced methods techniques used human genome bring a great opportunity researchers explore identify those or genes Human epidemiology new branch epidemiology, which leads study from molecular era wide association (GWAS). Here we review (especially ESCC) GWAS, provide an overview general genomic variants (genes, SNPs, miRNAs, proteins) ESCC.
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