Control of Osteoblast Function and Bone Extracellular Matrix Mineralization by Vitamin D

摘要: Vitamin D is the major regulator of calcium homeostasis and protects organism from deficiency via effects on intestine, kidney, parathyroid gland, bone. Disturbances in vitamin endocrine system, for example, D-dependent rickets type I II, result profound mineralization Also, recent studies with receptor (VDR) knockout mice show It questioned whether has a direct effect bone formation mineralization. In particular mice, supplementation restores However, (see Receptor section) present osteoblasts, affects expression various genes osteoblasts Introduction: Osteoblasts Effects Osteoblast Function Mineralization sections). regulates osteoblast activity not an independent manner but often interaction other hormones and/or growth factors section titled Interaction Other Factors).