Clinical aspects of LHRH analogues in gynaecology: a review

摘要: LHRH agonists are synthetic peptide analogues of hypothalamic luteinizing hormone releasing (LHRH) with superior potency and longer duration gonadotrophin release. Paradoxically, repeated administration causes pituitary desensitization diminished oestradiol secretion. A state hypogonadotrophic hypogonadism is reversibly induced; plasma oestrogen can be reduced to castrate levels. reliably induce anovulation but unlikely replace existing contraceptive methods in most normal women. By contrast these agents offer, for the first time, prospect inducing a reversible pseudomenopause essentially free side-effects. promise have profound impact upon management diverse range oestrogen-dependent gynaecological diseases both benign malignant. In particular, they may shortly become treatment choice endometriosis, as well becoming part common disorders such dysfunctional uterine bleeding fibroids.